Dose-Incidence Relationships on the Prenatal Effects of Gamma-Radiation in Mice.
- Author:
Dae Won BANG
1
;
Jong Hwan LEE
;
Heon OH
;
Se Ra KIM
;
Tae Hwan KIM
;
Yun Sil LEE
;
Cha Soo LEE
;
Sung Ho KIM
Author Information
1. College of Veterinary Medi cine,Chonnam National University,Kwangju 500-757, Korea. shokim@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Radiation;
Malformation;
Dose-incidence relationship;
ICR mouse
- MeSH:
Animals;
Bone and Bones/*abnormalities/radiation effects;
Congenital Abnormalities/embryology/epidemiology/*radionuclide imaging;
Female;
Fetal Death;
Fetal Resorption/epidemiology/radionuclide imaging;
*Gamma Rays;
Incidence;
Mice;
Mice, Inbred ICR;
Pregnancy;
*Prenatal Exposure Delayed Effects;
*Whole-Body Irradiation
- From:Journal of Veterinary Science
2002;3(1):7-11
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this investigation was to evaluate dose-incidence relationships on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed on day 11.5 after conception, coincident with the most sensitive stage for the induction of major congenital malformations, with 0.5-4.0 Gy of gamma-radiations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetuses, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. The threshold doses of radiation that induced cleft palate and dilatation of cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.
