Liposarcoma in the Extremity.
10.5292/jkbjts.2010.16.2.62
- Author:
Soo Hyun LEE
;
In je CHO
;
Woo Ick YANG
;
Jin Suck SUH
;
Kyoo Ho SHIN
- Publication Type:Original Article
- Keywords:
extremity;
liposarcoma;
disease free 5-year survival rate;
prognostic factor
- MeSH:
Disease-Free Survival;
Extremities;
Humans;
Liposarcoma;
Neoplasm Metastasis;
Recurrence;
Survival Rate
- From:The Journal of the Korean Bone and Joint Tumor Society
2010;16(2):62-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We analyzed disease free survival and the prognostic factors of liposarcoma in the extremity. MATERIALS AND METHODS: Between 1994 and 2005, of 44 patients who were diagnosed and treated for liposarcoma of the extremity, 40 patients were restrospectively analysed. 13 out of 40 patients got postoperative radiotherapy. We examined local recurrence, distant metastasis and disease free 5-year survival rate. We also analyzed clinical prognostic factors, such as age, gender, size of tumor, prior unplanned excision, histologic type, surgical excision margin and postoperative radiotherapy respectively. RESULTS: There were 3 cases of local recurrence and 4 cases of distant metastasis. The disease free 5-year survival rate was 85.0%. 26 patients presented with myxoid, 8 well differentiated, 4 round cell, 1 pleomorphic and 1 dedifferentiated histology. The disease free 5-year survival rate of mixoid, well differentiated and round cell liposarcoma were 100.0%, 84.6% and 75.0% (p=0.419). The 5-year disease free survival rate was 90.6% in negative surgical margin (n=25) and 62.5% in positive surgical margin (n=15) (p=0.003). CONCLUSION: Our study suggests that surgical excision margin is significant prognostic factor for 5-year disease free survival rate.
