Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors.
10.4062/biomolther.2016.199
- Author:
Michael FURLONG
1
;
Jae Young SEONG
Author Information
1. Graduate School of Biomedical Sciences, Korea University, Seoul 02841, Republic of Korea. jyseong@korea.ac.kr
- Publication Type:Review
- Keywords:
Neuropeptide;
7TMR;
G protein-coupled receptor;
Coevolution;
Gene duplication;
Whole genome duplication;
Evolutionary history
- MeSH:
Drug Design*;
Gene Duplication;
Genetic Association Studies;
Genome;
Genomics*;
Humans;
Ligands;
Neuropeptides*;
Vertebrates
- From:Biomolecules & Therapeutics
2017;25(1):57-68
- CountryRepublic of Korea
- Language:English
-
Abstract:
Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have been discovered via conventional bulk analysis techniques the increasing availability of structural and evolutionary data are facilitating change to rational, targeted drug design. This article discusses the appeal of neuropeptide-7TMR systems as drug targets and provides an overview of concepts in the evolution of vertebrate genomes and gene families. Subsequently, methods that use evolutionary concepts and comparative analysis techniques to aid in gene discovery, gene function identification, and novel drug design are provided along with case study examples.
