Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis.
10.4093/dmj.2015.39.5.414
- Author:
Jaechan LEEM
1
;
Eun Hee KOH
;
Jung Eun JANG
;
Chang Yun WOO
;
Jin Sun OH
;
Min Jung LEE
;
Joon Won KANG
;
Tae Hwan LIM
;
Chang Hee JUNG
;
Woo Je LEE
;
Joong Yeol PARK
;
Ki Up LEE
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. kulee@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Bilirubin;
Coronary artery disease;
Diabetes mellitus;
Multidetector computed tomography
- MeSH:
Angiography;
Bilirubin*;
Biomarkers;
Confounding Factors (Epidemiology);
Constriction, Pathologic;
Coronary Artery Disease;
Coronary Stenosis*;
Coronary Vessels*;
Cross-Sectional Studies;
Diabetes Mellitus;
Diagnosis;
Humans;
Logistic Models;
Multidetector Computed Tomography;
Odds Ratio;
Prevalence;
ROC Curve
- From:Diabetes & Metabolism Journal
2015;39(5):414-423
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The diagnosis of coronary artery disease (CAD) is often delayed in patients with type 2 diabetes. Serum total bilirubin levels are inversely associated with CAD. However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic diabetic patients at higher risk for having obstructive CAD. METHODS: We performed a cross-sectional study of 460 consecutive asymptomatic patients with type 2 diabetes. All patients underwent coronary computed tomographic angiography, and their serum total bilirubin levels were measured. Obstructive CAD was defined as > or =50% diameter stenosis in at least one coronary artery. RESULTS: Serum total bilirubin tertiles showed an inverse association with the prevalence of obstructive CAD. In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total bilirubin was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1 micromol/L in serum total bilirubin level was associated with a 14.6% decrease in obstructive CAD after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total bilirubin level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). CONCLUSION: Serum total bilirubin level is inversely associated with obstructive CAD and provides additive risk information over the FRS. Serum total bilirubin may be helpful for identifying asymptomatic patients with type 2 diabetes who are at higher risk for obstructive CAD.
