A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation.
- Author:
Sung Jin JEON
1
;
Tae Yong KIM
;
Seung Hoon LEE
;
Jong Sik KANG
;
Gwang Hyeon CHOI
;
Seung Gyu LEE
;
Hee Sang HWANG
Author Information
1. Department of Internal Medicine, Ulsan University College of Medicine, Seoul, Korea. tykim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Liver failure;
Liver transplantation;
Methimazole
- MeSH:
Antithyroid Agents;
Hepatitis;
Humans;
Hyperthyroidism;
Imidazoles;
Liver;
Liver Failure;
Liver Failure, Acute;
Liver Transplantation;
Methimazole;
Middle Aged;
Nitro Compounds;
Propylthiouracil;
Thyroid Gland;
Thyrotoxicosis
- From:Korean Journal of Medicine
2012;83(3):363-368
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antithyroid drugs inhibit the synthesis and excretion of thyroid hormone from the thyroid gland. Propylthiouracil (PTU) and methimazole are well known as antithyroid drugs. In 2011, the American Thyroid Association and American Association of Clinical Endocrinologists published management guidelines for hyperthyroidism and other causes of thyrotoxicosis, and recommended methimazole as the first-choice antithyroid drug for the treatment of hyperthyroidism. Lower hepatotoxicity is an advantage of methimazole. Fulminant hepatitis rarely occurs in methimazole users, and spontaneous recovery is expected even if it does occur. We describe a rare case of acute liver failure after methimazole intake in a 60-year-old man who underwent liver transplantation.
