Characteristics of Type 2 Diabetes in Terms of Insulin Resistance in Korea.
10.3349/ymj.2005.46.4.484
- Author:
Jong Suk PARK
1
;
Chul Sik KIM
;
Joo Young NAM
;
Dol Mi KIM
;
Min Ho JO
;
Jina PARK
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Hyun Chul LEE
;
Kap Bum HUH
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Insulin resistance;
type 2 diabetes;
Korea
- MeSH:
Adult;
Aged;
Blood Glucose/analysis;
C-Peptide/analysis;
Diabetes Mellitus, Type 2/*metabolism;
Female;
Hemoglobin A, Glycosylated/analysis;
Humans;
*Insulin Resistance;
Lipoproteins, HDL Cholesterol/blood;
Male;
Middle Aged;
Research Support, Non-U.S. Gov't
- From:Yonsei Medical Journal
2005;46(4):484-490
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin- resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p < 0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p < 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p < 0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.
