Influence of Bile Duct Ligation on 54 Liver Regeneration in Rats.
- Author:
Wook Hwan KIM
1
;
Jae Ho LEE
;
Seung Kyu JEONG
;
Hye Lee PARK
;
Yun Sik KWAK
;
Hee Jung WANG
;
Myung Wook KIM
Author Information
1. Department of Surgery, Ajou University School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Obstructive jaundice;
Partial hepatectomy
- MeSH:
Animals;
Bile Ducts*;
Bile*;
Common Bile Duct;
DNA;
Hepatectomy;
Jaundice, Obstructive;
Ligation*;
Liver Regeneration*;
Liver*;
Rats*;
Rats, Sprague-Dawley;
Regeneration;
Thymidine
- From:Journal of the Korean Surgical Society
1997;52(6):785-789
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
N/AWe evaluate the regenerating capacity of rat liver according to the severity and duration of the obstructive jaundice. Also we evaluate the regenerating capacity of hepatectomized rat liver according to the duration of the obstructive jaundice. The 10 week-old Sprague-Dawley rats were used. Common bile duct ligation and sequential partial hepatectomies were done. The regenerating capacity was measured by tritiated thymidine incorporation into rat liver DNA. The rate of incorporation of thymidine into DNA in the jaundiced livers increased significantly compared with that in the sham-operated liver on day 3.In jaundiced rats, the regenerating capacity after partial epatectomy decreased markedly without a return toward normal on day 3 and kept low thereafter. The duration of obstructive jaundice may be a key factor in the regeneration of rat liver after partial hepatectomy.
