Clinicopathologic Characteristica of the Mucinous Gastric Adenocarcinoma.
- Author:
Woo Jin HYUNG
1
;
Sung Hoon NOH
;
Yong Il KIM
;
Chang Hak RYU
;
Choong Bai KIM
;
Jin Sik MIN
;
Kyong Sik LEE
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Mucinous gastric adenocarcinoma;
Mucin content;
Clinicopathologic charac-teristicas
- MeSH:
Adenocarcinoma*;
Diagnosis;
Gastrectomy;
Humans;
Incidence;
Lymph Nodes;
Male;
Mucins*;
Neoplasm Metastasis;
Prognosis;
Stomach Neoplasms;
Survival Rate
- From:Journal of the Korean Surgical Society
1997;52(6):830-838
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There has been a considerable controversy on the prognosis of the mucinous gastric adenocarcinoma(MGC). In this study we analyzed the clinicopathologic differences between MGC and non-mucinous gastric carcinoma(NMGC). In addition, the relationship between mucin content and other clinicopathologic variables, including prognosis in MGC was examined. We reviewed 2118 patients with pathologically confirmed gastric cancer who had underwent gastrectomy at the department of surgery of Yonsei University College of Medicine, during the period between Jan. 1987 and Dec. 1993. Among them, 130 patients had gastric cancer with extracellular mucin(MGC) and 1988 patients had gastric carcinoma without extracellular mucin(NMGC). We studied the MGC patients into two groups according to mucin content: mucin content involving over 50% of the tumor(dominant type, n=94) and mucin content involving less than 50% of the tumor area(partial type, n=36). The results are as follows: The MGC was more common in male then NMGC. The size of tumor in MGC was larger than that of NMGC. The patients with MGC had higher incidence of Borrmann type IV, more frequent serosal invasion, lymph nodes metastasis and peritoneal metastasis than the patients with NMGC. The patients with MGC had more advanced stage at the time of diagnosis and worse overall 5-year survival rate than the patients with NMGC. But the 5-year survival rate according to the stage of MGC was similar to that of NMGC. There were no significant differences between the mucin content and other pathologic variables including prognosis. So we suggested that MGC has worse prognosis than NMGC and it is reasonable to consider the carcinoma with mucin content involving less than 50% of the tumor area as MGC.
