Changing patterns of Pancreatic enzyme after Distal Gastrectomy and the Effect of Protease Inhibitor Treatment.
- Author:
Sung Tae OH
1
;
Wan Soo KIM
;
Byung Sik KIM
Author Information
1. Department of Surgery, University of Ulsan, College of Medicine, and Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Gastrectomy;
Protease inhibitor;
Amylase;
Lipase;
FOY
- MeSH:
Amylases;
Gabexate;
Gastrectomy*;
Humans;
Hyperamylasemia;
Lipase;
Pancreas;
Pancreatic Fistula;
Prospective Studies;
Protease Inhibitors*
- From:Journal of the Korean Surgical Society
1997;52(6):846-851
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We have reported that serum amylase and lipase level elevate immediately after total gastrectomy independent to whether the pancreas is manipulated or not. Although we found high levels of amylase and lipase from the draining fluid via intraabdominal drain, none of them became pancreatic fistula. To check the amylase and lipase level after distal gastrectomy and to check whether the protease inhibitor (gabexate mesilate) reduce the elevated amylase and lipase, we made a prospective study. A Jackson-Pratt drain was inserted intraperitoneally during the operation to check amylase and lipase levels postoperatively. We present the postoperative changing patterns of amylase and lipase levels in the draining fluid. Serum amylase and lipase levels were also monitored. We found elevation of amylase and lipase concentrations in the draining fluid for a few days after distal gastrectomy. However, none of the patients developed pancreatic fistula, although all of the surgical methods showed hyperamylasemia and hyperlipasemia. Postoperative treatment with protease inhibitor was not effective against the elevated amylase and lipase levels in serum or draining fluid.
