Memantine Reverses Social Withdrawal Induced by Ketamine in Rats.
- Author:
Ezequiel URIBE
1
;
Jose LANDAETA
;
Richard WIX
;
Antonio EBLEN
Author Information
- Publication Type:Original Article
- Keywords: experimental psychosis; ketamine; NMDA; haloperidol; social interaction test
- MeSH: Animals; Haloperidol; Interpersonal Relations; Ketamine; Memantine; Motor Activity; N-Methylaspartate; Rats; Schizophrenia
- From:Experimental Neurobiology 2013;22(1):18-22
- CountryRepublic of Korea
- Language:English
- Abstract: The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg.kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg.kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
