Low-dose Clozapine-induced Seizure: A Case Report.
10.9758/cpn.2017.15.2.190
- Author:
Abdullah BOLU
1
;
Süleyman AKARSU
;
Erdal PAN
;
Emre AYDEMIR
;
Taner OZNUR
Author Information
1. Aircrew's Health Research and Training Center, Eskişehir, Turkey.
- Publication Type:Case Report
- Keywords:
Clozapine;
Adverse effects;
Seizures;
Safety
- MeSH:
Adult;
Clozapine;
Diagnosis;
Electroencephalography;
Humans;
Male;
Plasma;
Schizophrenia;
Seizures*
- From:Clinical Psychopharmacology and Neuroscience
2017;15(2):190-193
- CountryRepublic of Korea
- Language:English
-
Abstract:
Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.
