Clinical and Biological Features of Interval Colorectal Cancer.

Author: Yu Mi LEE ¹ ; Kyu Chan HUH
Author Information

1. Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
Publication Type:Review
Keywords: Interval colorectal cancers; Colonoscopy
MeSH: Carcinogenesis; Colon; Colonic Neoplasms; Colonoscopy; Colorectal Neoplasms*; Comorbidity; Diverticulum; Female; Humans
From:Clinical Endoscopy 2017;50(3):254-260
CountryRepublic of Korea
Language:English
Abstract: Interval colorectal cancer (I-CRC) is defined as a CRC diagnosed within 60 months after a negative colonoscopy, taking into account that 5 years is the “mean sojourn time.” It is important to prevent the development of interval cancer. The development of interval colon cancer is associated with female sex, old age, family history of CRC, comorbidities, diverticulosis, and the skill of the endoscopist. During carcinogenesis, sessile serrated adenomas/polyps (SSA/Ps) share many genomic and colonic site characteristics with I-CRCs. The clinical and biological features of I-CRC should be elucidated to prevent the development of interval colon cancer.