Acute oxalate nephropathy caused by ethylene glycol poisoning.
- Author:
Jung Woong SEO
1
;
Jong Ho LEE
;
In Sung SON
;
Yong Jin KIM
;
Do Young KIM
;
Yong HWANG
;
Hyun Ah CHUNG
;
Hong Seok CHOI
;
So Dug LIM
Author Information
1. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. nephlee@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Acute kidney injury;
Calcium oxalate;
Ethylene glycol;
Metabolic acidosis
- MeSH:
Acidosis;
Acute Kidney Injury;
Biopsy;
Calcium Oxalate;
Central Nervous System;
Depression;
Ethylene Glycol;
Ethylenes;
Glycolates;
Glyoxylates;
Kidney;
Oxalic Acid
- From:Kidney Research and Clinical Practice
2012;31(4):249-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, and kidney injury. Oxalic acid is the end product of EG, which can precipitate to crystals of calcium oxalate monohydrate in the tubular lumen and has been linked to acute kidney injury. We report a case of EG-induced oxalate nephropathy, with the diagnosis confirmed by kidney biopsy, which showed acute tubular injury of the kidneys with extensive intracellular and intraluminal calcium oxalate monohydrate crystal depositions.
