Acute Hepatic Failure Associated with Stevens-Johnson Syndrome Induced by Carbamazepine Treatment in a Patient with Transverse Myelitis.
10.4174/jkss.2011.80.2.157
- Author:
Bum Soo KIM
1
;
Sun Hyung JOO
;
Hak Young RHEE
;
Ho Cheol PARK
Author Information
1. Department of Surgery, Kyung Hee University School of Medicine and the Kyung Hee University Hospital at Gangdong, Seoul, Korea. sunhyung@chol.com
- Publication Type:Case Report
- Keywords:
Carbamazepine;
Stevens-Johnson syndrome;
Fulminant hepatic failure;
Liver transplantation;
Transverse myelitis
- MeSH:
Blister;
Carbamazepine;
Consciousness;
Female;
Hepatic Insufficiency;
Humans;
Jaundice;
Liver;
Liver Failure;
Liver Failure, Acute;
Liver Transplantation;
Middle Aged;
Myelitis, Transverse;
Stevens-Johnson Syndrome;
Tissue Donors;
Transplants
- From:Journal of the Korean Surgical Society
2011;80(2):157-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
Carbamazepine-induced liver injury is less common, but the consequences of the side effects can be very serious leading to death or a need for liver transplantation. We report a case of a 60-year-old female transverse myelitis patient with fulminant hepatic failure and Stevens-Johnson syndrome induced by carbamazepine who successfully underwent deceased donor liver transplantation. The patient, a 60-year-old female, was admitted to our service due to acute liver insufficiency and a drowsy mental state attributable to carbamazepine. She had been treated with carbamazepine to control transverse myelitis. Fifty days after the use of carbamazepine, she developed jaundice, erythematous papules and bullae, and decreased consciousness. The diagnosis of Stevens-Johnson syndrome was considered. She underwent deceased donor liver transplantation. She was discharged with normal graft functions 5 months after transplantation. Thus, liver transplantation can be a feasible therapy for patients with carbamazepine-induced hepatic failure associated with Stevens-Johnson syndrome.
