Relationship between Serum Insulin-like Growth Factor-1 Concentration and Insulin Resistance in End-stage Renal Disease Patients.
- Author:
Seoung Woo LEE
1
;
Keum Ho LEE
;
Geun Ho PARK
;
Seung Won LEE
;
Joon Ho SONG
;
Moon Jae KIM
Author Information
1. Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Kidney Disease Research Group in Inha Research Institute for Medical Sciences of Inha University, Incheon, Korea. nhkimj@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Insulin-like growth factor-1;
Insulin resistance;
Chronic renal failure;
Body composition
- MeSH:
Absorptiometry, Photon;
Body Composition;
Body Mass Index;
Body Weight;
Classification;
Dialysis;
Glucose;
Homeostasis;
Humans;
Insulin Resistance*;
Insulin*;
Insulin-Like Growth Factor I;
Kidney Failure, Chronic*;
Malnutrition;
Multivariate Analysis;
Overweight;
Plasma;
Prealbumin;
Thinness;
Uremia
- From:Korean Journal of Nephrology
2005;24(3):375-383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Insulin resistance is a characteristic feature of uremia and recent studies suggested that it might be one of the causes of muscle wasting. Serum insulin-like growth factor 1 (IGF-1) has been known as one of marker of malnutrition in end-stage renal disease (ESRD) patients. However, there were few studies on the relationship between IGF-1 and insulin resistance. METHODS: We measured serum IGF-1, prealbumin, albumin, plasma insulin and glucose concentration and body composition by dual energy X-ray absorptiometry in 20 non-diabetic ESRD patients who admitted to start dialysis. Homeostasis model assessment method of insulin resistance (HOMA-IR) was used for insulin resistance. RESULTS: Patients with IGF-1 <200 ng/mL (n=6) had significantly lower body weight (BW), body mass index (BMI), prealbumin (29.8+/-7.0 vs. 39.7+/-9.3 mg/ dL, p=0.022), Fat mass, pFat (percent fat mass), pFat-limb and HOMA-IR (1.44+/-0.59 vs. 3.47+/-2.22, p=0.04) than those with >200 ng/mL (n=14). IGF-1 showed positive correlations with BMI (r=0.45), prealbumin (r=0.6), Fat-limb (r=0.51), and HOMA-IR (r=0.67). On WHO classification for weight status, IGF-1 seemed to be higher when weight status was increased from underweight (151.8+/-41.6 ng/mL) to overweight (371.8+/-109.8 ng/mL) and these trends were similar to those of HOMA-IR. On multivariate analysis, IGF-1 was independent variable for affecting HOMA-IR. CONCLUSION: Serum IGF-1 concentration seems to be associated with insulin resistance in ESRD patients and reflect body composition, especially fat mass.
