Immunohistochemical comparison of the telomerase expression between low-grade and high-grade gastric dysplasia.
- Author:
Young Sang OH
1
;
Ho Dong KIM
;
Seung Won MOON
;
Jong Hyeok JEONG
;
Dong Han KIM
;
Hyuk Seung YANG
;
Soo Hyun KIM
;
Sang Pil KIM
;
Won Jeong JEON
;
Hyeuk PARK
;
Jeong Young CHOI
;
Do Hyun KIM
;
Young Jik LEE
Author Information
1. Department of Internal Medicine, St. Carollo Hospital, Suncheon, Korea. rapael64@hanmail.net
- Publication Type:Original Article
- Keywords:
Dysplasia;
Telomerase;
Immunohistochemistry
- MeSH:
Carcinogenesis;
Eukaryotic Cells;
Humans;
Immunohistochemistry;
Telomerase*;
Telomere
- From:Korean Journal of Medicine
2007;72(4):368-375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Telomeres are simple repeats elements located at each end of the chromosomes of eukaryotic cells. The main function of telomeres is to cap the chromosome end and protect it from enzymatic attack. Telomerase that facilitates the synthesis of telomere has been detected in not only cancer, but also in precancerous lesion. In this study, we compared the telomerase expression between low-grade and high-grade gastric dysplasia. METHODS: The telomerase expression of 43 patients with gastric dysplasia (22 low-grade and 21 high-grade) was evaluated by immunohistochemical staining in tissues. RESULTS: The telomerase expression was much higher in the tissues from the patients with high-grade gastric dysplasia than in those tissues of the patients with low-grade gastric dysplasia. CONCLUSIONS: Activation of telomerase may be related with the malignant potentiality in gastric cells. Further studies are needed to define the role of telomerase in gastric tumorigenesis.
