Parvovirus B19 infection-associated hemophagocytic lymphohistiocytosis.
- Author:
Hyeok SHIM
1
;
Hyun Jung KIM
;
Young Jin LEE
;
Moo Rim PARK
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. mrpark21@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Lymphohistiocytosis;
hemophagocytic;
Parvovirus B19;
human
- MeSH:
Adolescent;
Blood Cells;
Bone Marrow;
Erythroblasts;
Fever;
Histiocytes;
Humans;
Hypertriglyceridemia;
Immunoglobulin M;
Intranuclear Inclusion Bodies;
Liver;
Lymph Nodes;
Lymphohistiocytosis, Hemophagocytic*;
Male;
Pancytopenia;
Parvovirus*;
Polymerase Chain Reaction;
Reticulocyte Count;
Spleen
- From:Korean Journal of Medicine
2007;72(4):433-436
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemophagocytic lymphohistiocytosis is an unusual syndrome that's characterized by fever, hepatosplenomegaly, cytopenias, hypertriglyceridemia, hypofibrinogenemia and pathologic finding of hemophagocytosis in the bone marrow and other tissues. A previously healthy 16-year-old male was admitted because of fever. The cervical and axillary lymph nodes, liver and spleen were palpable. CBC revealed pancytopenia with a decreased reticulocyte count, and the bone marrow aspiration smear showed the presence of giant pronormoblasts with intranuclear inclusion bodies and an increased number of histiocytes that were engulfing blood cell. IgM antibody against Parvovirus B19 and PCR for Parvovirus B19 were positive. Thus, he was diagnosed with hemophagocytic lymphohistiocytosis that was caused by Parvovirus B19 infection. Parvovirus B19 is an agent rarely associated with hemophagocytic lymphohistiocytosis, and in most cases it occurs in those patients with an underlying disease. We report here on a case of hemophagocytic lymphohistiocytosis associated with acute Parvovirus B19 infection in healthy male.
