Thyroid autoantibodies and thyroid dysfunction in rheumatoid arthritis.
- Author:
Yong Wook LEE
1
;
Dong Sun KIM
;
Tae Young KIM
;
Chang Beom LEE
;
Yong Soo PARK
;
Woong Hwan CHOI
;
Tae Wha KIM
;
Think You KIM
;
Jae Bum JUN
;
Sang Cheol BAE
;
Dae Hyun YOU
;
Seong Yoon KIM
Author Information
1. Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
Thyroid autoantibodies;
Thyroid disorder
- MeSH:
Arthritis, Rheumatoid*;
Autoantibodies*;
Connective Tissue;
Euthyroid Sick Syndromes;
Female;
Hemagglutinins;
Humans;
Hyperthyroidism;
Hypothyroidism;
Luminescence;
Nephelometry and Turbidimetry;
Prevalence;
Rheumatoid Factor;
Thyroid Diseases;
Thyroid Gland*;
Thyroiditis, Autoimmune
- From:Korean Journal of Medicine
2000;58(3):317-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Autoimmune thyroid diseases have been shown to occur in association with connective tissue disorders. This study was undertaken to elucidate the prevalence of thyroid autoantibodies and thyroid dysfunction in Korean patients with rheumatoid arthritis (RA). METHODS: We have compared the prevalence of thyroid autoantibodies in 108 RA patients with 81 age-matched controls. Antimicrosomal antibody (AMA) and antithyroglobulin antibody (ATA) were measured by passive hemagglutinin assay. T3, T4, Free T4, and TSH were measured by chemiluminescence method. Rheumatoid factor was measured by nephelometry. Statistical analysis was performed by chi-square, Fisher's exact test, and Pearson correlation test. RESULTS: 1) The presence of AMA/ATA in patients with RA was significantly higher (28.7%/26.7% in 108 patients) than that of controls (11.1%/9.9% in 81 controls). The positive rates of AMA/ATA in female patients were also higher (28.9%/28.9% in 97 patients) than those of female controls (15.5%/12.1% in 58 controls). 2) Thirty three (17.6%) of 187 patients with RA had the abnormalities of thyroid function; 14 (7.5%) revealed subclinical hypothyroidism, 5 (2.7%) revealed biochemical primary hypothyroidism, 7 (3.7%) revealed sick euthyroid syndrome, and 7 (3.7%) revealed hyperthyroidism. CONCLUSION: These results suggest that autoimmune thyroiditis is highly associated with RA in Korean patients, showing the increased prevalence of thyroid autoantibodies and thyroid dysfunctions.
