A case of prophylthiouracil associated ANCA positive acute glomerulonephritis.
- Author:
Seok Jae HWANG
1
;
Young Seol KIM
;
Hak Reol NAA
;
Seung Joon OH
;
In Myung YANG
;
Jin Woo KIM
;
Young Kil CHOI
;
Moon Ho YANG
Author Information
1. Department of Internal Medicine, Kunghee University, College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Prophylthiouracil;
Antineutrophil Cytoplasmic Autoantibodies;
Glomerulonephritis
- MeSH:
Adult;
Antibodies, Antineutrophil Cytoplasmic*;
Antithyroid Agents;
Biopsy;
Edema;
Female;
Glomerulonephritis*;
Hematuria;
Humans;
Peroxidase;
Prednisolone;
Thyrotoxicosis;
Vasculitis
- From:Korean Journal of Medicine
2000;58(3):330-334
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vasculitis is a rare complication of antithyroid drugs. Recently it was reported in association with ANCA. In most cases, the ANCA was specific for myeloperoxidase. The glomerulonephritis was key clinical manifestation in majority of cases. When antithyroid drugs were discontinued, clinical disease generally improved and ANCA titers were tended to fall. We experienced a 44 year old woman who presented with gross hematuria and generalized edema, after she had been treated with prophylthiouracil for 6 week for thyrotoxicosis. Renal biopsy was done, which showed mesangial proliferative glomerulonephritis. Indirect immunoflurorescence staining showed highly positive perinuclear pattern of ANCA in her serum. Prophylthiouracil associated ANCA positive glomerulonephritis was suspected. After cessation of prophylthiouracil and administration of prednisolone, renal function recovered gradually and ANCA titers were reduced. We hereby report a case of prophylthiouracil associated ANCA positive glomerulonephritis with a brief review of literature.
