Clinical Significance of Growth Hormone, Insulin-like Growth Factor-1, and Insulin-like Growth Factor Binding Protein-3 in Patients With Posthepatitic Liver Cirrhosis.
- Author:
Jae Hyeon MOON
1
;
Do Hoon KIM
;
Jin Kwang AN
;
Jun Hong LEE
;
Dae Hwan KANG
;
Geun Am SONG
;
Mong CHO
;
Ung Suk YANG
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Growth hormone;
Insulin-like growth factor-1;
Insulin-like growth factor binding protein-3;
Liver cirrhosis
- MeSH:
Alcoholics;
Bilirubin;
Dissent and Disputes;
Fasting;
Fibrosis;
Growth Hormone*;
Hepatitis B;
Humans;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor I;
Liver Cirrhosis*;
Liver Cirrhosis, Alcoholic;
Liver*;
Prothrombin Time
- From:The Korean Journal of Hepatology
2000;6(1):52-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Although an Insulin-like growth factor-1(IGF-1) and an Insulin-like growth factor binding protein-3(IGFBP-3) have been reported to be valuable indices of nutritional state in cirrhotic patients, there is still a dispute. The controversy may be caused by the fact that most studies included heterogeneous groups of patients such as alcoholic and posthepatitic cirrhosis. The aim of this study was two fold: to evaluate whether the Growth hormone(GH), IGF-1, and the IGFBP-3 are significant or not as valuable indices of hepatic function as well as the nutritional state in hepatitis B or C associated cirrhotic patients. METHODS: This study consisted of 36 patients with liver cirrhosis associated with hepatitis B or C. Patients with alcoholic cirrhosis were excluded. The serum GH, IGF-1, and IGFBP-3 were measured while patients were fasting. The variables of liver function and nutritional state included Child-Pugh score, serum bilirubin, albumin, prothrombin time, triceps skinfold thickness(TSF), and midarm muscle circumference (MAMC). The correlation between the variables of liver function or nutritional state and the serum GH, IGF-1, or IGFBP-3 was evaluated. RESULTS: The IGF-1 correlated very well with IGFBP-3 (p<0.001). Both the IGF-1 and IGFBP-3 correlated inversely with Child-Pugh score (p<0.01, P<0.001 respectively). IGFBP-3 correlated very well with the serum bilirubin level as well as the albumin level (p<0.001). Neither the IGF-1 nor IGFBP-3 showed any correlation with TSF or MAMC. CONCLUSIONS: Both IGF-1 and IGFBP-3 were clinically significant as indices of hepatic function in the patients with hepatitic B or C associated cirrhosis but neither of them were significant as indices of nutritional state.
