Familial Dilated Cardiomyopathy.
10.4070/kcj.1997.27.10.1037
- Author:
Byung Hee OH
;
Kwang Il KIM
;
Moo Yong RHEE
;
In Ho CHAE
;
Hyo Soo KIM
;
Dae Won SOHN
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
;
Young Woo LEE
- Publication Type:Case Report
- Keywords:
Familial dilated cardiomyopathy
- MeSH:
Bacterial Infections;
Cardiomyopathies;
Cardiomyopathy, Dilated*;
Dilatation;
Genes, Mitochondrial;
Heart Failure;
Humans;
Molecular Biology;
Muscular Dystrophies;
Prevalence;
Rare Diseases;
Thiamine Deficiency;
United States;
Ventricular Dysfunction, Left;
Wills
- From:Korean Circulation Journal
1997;27(10):1037-1043
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dilated cardiomyopathy is a primary myocardial disease characterized by ventricular dilatation and impaired ventricular contractility. It is not a rare disease and the age-adjusted prevalence in the United States is 36 cases per 100,000 population. The etiology of dilated cardiomyopathy has not been known yet, but toxin such as alcohol, thiamine deficiency, endocrine disorder, viral or bacterial infection, hereditary disorder, muscular dystrophy may be related to dilated cardiomyopathy. Familial dilated cardiomyopathy has been considered to be a rare disorder. But in recent study, dilated cardiomyopathy is found to be familial in at least 20%, a considerably higher prevalence than the previous reports. The mode of inheritance in most cases appears to be autosomal dominant, but there are reports of autosomal recessive, X-linked recessive, and mitochondrial inheritance. With molecular genetic technology, genomic abnormality responsible for familial dilated cardiomyopathy is being identified. The detection of responsible geneallows the determination of the gene-carrier status. We report a family with dilated cardiomyopathy, where two patients died suddenly, one patient has symptomatic heart failure, and another two family members have asymptomatic left ventricular dysfunction, identified by echocardiogram.
