Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients.
10.3346/jkms.2012.27.10.1162
- Author:
Young Kwang SHIM
1
;
Jeong Tae KIM
;
Mun Hyuk SEONG
;
Yeon Jeong KIM
;
Tae Jin SHIM
;
Sang Min KIM
;
Sang Yeub LEE
;
Jang Whan BAE
;
Ki Seok KIM
;
Kyung Kuk HWANG
;
Dong Woon KIM
;
Myeong Chan CHO
Author Information
1. Regional Cardiovascular Disease Center, Division of Cardiology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea. drcorazon@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Myocardial Infarction;
Thioredoxins;
Biochemical Markers;
Oxidative Stress
- MeSH:
Acute Disease;
Adult;
Aged;
Biological Markers/blood;
Coronary Angiography;
Creatine Kinase/blood;
Creatine Kinase, MB Form/blood;
Echocardiography;
Female;
Humans;
Male;
Middle Aged;
Myocardial Infarction/*blood/pathology;
Myocardium/*pathology;
Percutaneous Coronary Intervention;
Thioredoxins/*blood;
Troponin T/blood
- From:Journal of Korean Medical Science
2012;27(10):1162-1169
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 +/- 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 +/- 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 +/- 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI.
