Effect of Helicobacter pylori Eradication According to the IL-8-251 Polymorphism in Koreans.
10.3346/jkms.2012.27.10.1202
- Author:
Hae Yeon KANG
1
;
Sang Gyun KIM
;
Mi Kyung LEE
;
Joo Sung KIM
;
Hyun Chae JUNG
;
In Sung SONG
Author Information
1. Department of Internal Medicine and Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter pylori;
Interleukin-8;
Polymorphism
- MeSH:
Aged;
Alleles;
Angiopoietin-1/analysis;
Anti-Bacterial Agents/therapeutic use;
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use;
Asian Continental Ancestry Group/*genetics;
Female;
Gastric Mucosa/metabolism/pathology;
Genotype;
Helicobacter Infections/*drug therapy;
*Helicobacter pylori;
Humans;
Interleukin-8/analysis/*genetics;
Male;
Matrix Metalloproteinase 9/analysis;
Middle Aged;
*Polymorphism, Single Nucleotide;
Proton Pump Inhibitors/therapeutic use;
Republic of Korea;
Retrospective Studies;
Stomach Neoplasms/pathology/surgery;
Time Factors;
Vascular Endothelial Growth Factor A/analysis
- From:Journal of Korean Medical Science
2012;27(10):1202-1207
- CountryRepublic of Korea
- Language:English
-
Abstract:
Previous studies suggested that polymorphisms of proinflammatory cytokine genes are important host genetic factors in Helicobacter pylori infection. The present study evaluated whether IL-8-251 polymorphism affected H. pylori eradication rate and to investigate the effect of H. pylori eradication on angiogenesis and the inflammatory process according to the IL-8-251 polymorphism. A total of 250 H. pylori-positive patients treated by endoscopic resection of the gastric neoplasm were classified into 3 groups (134 H. pylori-eradicated group, 19 H. pylori-eradication failure group, and 97 H. pylori-infected group). H. pylori status, histology, and angiogenic factor levels were evaluated at baseline, 6 months, and 18 months. H. pylori eradication rate was 92.9% in AA genotype, 85.7% in AT genotype and 88.4% in TT genotype (P value = 0.731). Elevated IL-8 and matrix metalloproteinase-9 concentrations in H. pylori-infected gastric mucosa were reversible by successful eradication of H. pylori, independent of the IL-8-251 polymorphism. It is suggested that elevated IL-8 and MMP-9 concentrations in H. pylori-infected gastric mucosa are altered significantly after successful eradication and these conditions continue for 18 months. However, IL-8-251 polymorphism does not affect H. pylori eradication rate and the sequential changes of related angiogenic factors after H. pylori eradication in Koreans.
