Tardive Dyskinesia and CAG Repeat Expansions.
- Author:
Sang Kyeong LEE
1
;
Jae Hoon PARK
;
Sung Woo PARK
;
Joo Chul SHIM
;
Sang Soo LEE
;
Chung Goo RHEE
;
Jung Mee AHN
;
Doh Kwan KIM
;
Young Hoon KIM
Author Information
1. Department of Neuropsychiatry, School of Medicine and Institute of Neuroscience, Inje University, Busan, Korea.
- Publication Type:Original Article
- Keywords:
CAG repeat expansion;
Schizophrenia;
Tardive dyskinesia;
Repeat expansion
- MeSH:
DNA;
Dyskinesias;
Humans;
Huntington Disease;
Ligation;
Movement Disorders*;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
2002;41(3):399-408
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Much interest has recently been focused on the possibility of the involvement of unstable DNA in the etiology of schizophrenia following several publications that reported increases in frequency of large CAG repeats in affected individuals. Tardive dyskinesia(TD), an involuntary movement disorder following pharmacological treatment of schizophrenia, shares a great deal of common clinical and biological features with Huntington's disease, a representative movement disorder with CAG repeat expansions. The authors studied for a possible CAG repeat expansions in patients with schizophrenia and TD. METHODS: TD was diagnosed by the Abnormal Involuntary Movement Scale. Using repeat expansion detection(RED), a method in which a thermostable ligase is used to detect repeat expansions directly from genomic DNA, subjects with schizophrenia with/without TD(n=79/n=75) and normal controls (n=72) were studied for the presence of the CAG repeat expansions were analyzed. RESULTS: No significant size differences were detected in the(CTG)17 ligation products between schizophrenic cases and controls using RED(X(2)=2.907, df=2, p=0.234). CONCLUSIONS: This finding does not support the hypothesis that CAG repeat expansions contributes to the susceptibility for schizophrenia and TD.
