Effect of Mirtazapine in Patients with Posttraumatic Stress Disorder: A Pilot Study.
- Author:
Won Myong BAHK
1
;
Chi Un PAE
;
Hak Jae JUNG
;
Jeong Ho CHAE
;
Tae Youn JUN
;
Kwang Soo KIM
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Mirtazapine;
PTSD
- MeSH:
Depression;
Follow-Up Studies;
Humans;
Pilot Projects*;
Stress Disorders, Post-Traumatic*
- From:Journal of Korean Neuropsychiatric Association
2002;41(3):454-460
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was conducted to evaluate the effects of mirtazapine in patients with posttraumatic stress disorder(PTSD). METHOD: 15 patients who were diagnosed as PTSD were treated with mirtazapine for 8 weeks. Efficacy measurement and side-effects monitoring were performed at baseline, in 4 and 8 week. PTSD and depression were assessed at each follow-up visits using the following measures : Interviewer-Administered Structured Interview for PTSD(SIP), Short PTSD Rating Interview(SPRINT), Impact of Event Scale-Revised(IES-R), The Montgomery Asberg Depression Rating Scale(MADRS). RESULTS: Significant reduction of SIP, SPRINT, IES-R, and MADRS was observed after 8 weeks administration of mirtazapine. No serious drug-related side effects occurred. CONCLUSION: The results suggest that mirtazapine may be an effective agent in the treatment of patients with PTSD. More sophisticated study would be necessary.
