Treatment of Generalized Granuloma Annulare with Low-dose Hydroxychloroquine.
- Author:
Chi Yeon KIM
1
;
Sang Young PARK
;
Chee Won OH
Author Information
1. Department of Dermatology, School of Medicine, Gyeongsang National University, Jinju, Korea. deroh@nongae.gnu.ac.kr
- Publication Type:Case Report
- Keywords:
Granuloma annulare;
Generalized;
Hydroxychloroquine;
Low dose
- MeSH:
Chronic Disease;
Diabetes Mellitus;
Extremities;
Granuloma Annulare*;
Granuloma*;
Humans;
Hydroxychloroquine*;
Lupus Erythematosus, Systemic;
Middle Aged;
Skin Diseases
- From:Korean Journal of Dermatology
2007;45(9):969-972
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Generalized granuloma annulare (GGA) is benign granulomatous dermatosis of unknown causes characterized by a widespread papular eruption on the trunk and limbs. This differs from the localized form as it is distinguished by later onset, a protracted response to therapy, and concomitant diabetes mellitus in 20% of patients. GGA is a chronic disease with a relapsing course and a poor long term response to treatment, GGA lasted for 5 or more years in 25% of patients. Thus, more safe and effective therapeutic modalities are needed. The effectiveness and safety of hydroxychloroquine (6.5 mg/kg/day) which has a long history of efficacy in systemic lupus erythematosus is identified. We report a case of 48-year-old man presented with GGA lesions successfully treated with a low dose hydroxychloroquine (3 mg/kg/day) without side effect and the clinical improvement observed after 2 weeks. Low doses of hydroxychloroquine might be beneficial in the treatment of GGA, compared with other drugs, with low potency of side effect.
