A case of spontaneous intracerebral hemorrhage in neurofibromatosis type 1 associated with pheochromocytoma.
- Author:
Moo Gon KIM
1
;
Jin Bae LEE
;
Seung Pyo HONG
;
So Yern KIM
;
Young Soo LEE
;
Jae Kean RYU
;
Ji Yong CHOI
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jblee@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Neurofibromatosis;
Pheochromocytoma;
Intracerebral hemorrhage
- MeSH:
Adult;
Cerebral Hemorrhage;
Delayed Diagnosis;
Female;
Headache;
Hemorrhage;
Humans;
Hypertension;
Mass Screening;
Nausea;
Neurofibromatoses;
Neurofibromatosis 1;
Pheochromocytoma;
Vomiting
- From:Korean Journal of Medicine
2008;75(1):103-107
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Spontaneous intracerebral hemorrhage is very rare in patients with neurofibromatosis type 1. A 30-year-old woman was referred to our hospital for evaluation of headaches, nausea, and vomiting. She was diagnosed with neurofibromatosis type 1 and a spontaneous intracerebral hemorrhage. She was treated with conservative management, including antihypertensive medications for 32 months. However, because of sustained hypertension, we performed screening tests for a pheochromocytoma. The 24 hr urine VMA and urine metanephrines were elevated. Abdominal CT showed a right adrenal mass, 7.5 x 5.8 cm in size.. After a successful resection of the tumor, the hypertension resolved without medication for > 1 year. This case illustrates that delayed diagnosis and treatment of pheochromocytoma can cause serious complications from hypertension, such as cerebrovascular hemorrhage. Thus, in patients with neurofibromatosis and hypertension, screening for pheochromocytoma is important for the early detection of an adrenal tumor.
