Effects of Intravitreal Amniotic Membrane Injection in a Rat Model of Choroidal Neovascularization.
10.3341/jkos.2008.49.7.1154
- Author:
Jong Hyun LEE
1
;
Jae Lim CHUNG
;
Samin HONG
;
Hyoung Jun KOH
Author Information
1. Department of Ophthalmology, Ilsan Paik Hospital, Inje University, Goyang-si, Korea.
- Publication Type:Original Article
- Keywords:
Amniotic membrane;
Angiogenesis;
Choroidal neovascularization
- MeSH:
Amnion;
Angiography;
Animals;
Choroid;
Choroidal Neovascularization;
Eye;
Intravitreal Injections;
Rats
- From:Journal of the Korean Ophthalmological Society
2008;49(7):1154-1158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effects of an intravitreal amniotic membrane (AM) injection on a rat model of laser-induced choroidal neovascularization (CNV). METHODS: Intravitreal injection of AM (12.5 microgram/mL) into the left eyes and phosphate-buffered saline into the fellow eyes of 15 rats was performed immediately after laser injury. At week 2, after angiography, the rats were sacrificed, and histopathologic analysis was performed. Angiographic and histopathologic assessments of the effects of AM injection on CNV growth were compared between the two groups. RESULTS: CNV thickness was found to have increased more in the AM treatment group (141.54+/-8.12 micrometer) than in the experimental control group (65.23+/-16.90 micrometer) (p=0.010). CONCLUSIONS: Intravitreal AM injection demonstrated histopathologic pro-angiogenic properties in a rat model of CNV.
