Multiple myeloma and chronic myelogenous leukemia: a case report with literature review.
10.3349/ymj.1993.34.3.293
- Author:
Philip J KLENN
1
;
Bong H HYUN
;
Young Hee LEE
;
Wen Yu ZHENG
Author Information
1. Department of Pathology and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
- Publication Type:Case Report ; Review
- Keywords:
Multiple myeloma;
chronic myelogenous leukemia
- MeSH:
Aged;
Case Report;
Cell Transformation, Neoplastic/pathology;
Hematopoietic Stem Cells/pathology;
Human;
Leukemia, Myeloid, Chronic/*pathology;
Male;
Multiple Myeloma/*pathology
- From:Yonsei Medical Journal
1993;34(3):293-300
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is the case of a 71 year old male who developed multiple myeloma (MM) and chronic myelogenous leukemia (CML) within a two year period. The patient initially presented with osteolytic lesions of the lumbar spine, and following the initial work-up a diagnosis of multiple myeloma with an IgG kappa paraproteinemia was made and appropriate treatment was given. Two years later the patient developed a progressively worsening leukocytosis which was found to be due to Philadelphia Chromosome (Ph1) positive CML. The occurrence in the same patient of two distinct hematologic malignancies suggests a neoplastic transformation of a pluripotent stem cell. A review of the literature appears to support the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders.
