Vanishing Pancreatic Grafts.
10.3349/ymj.2004.45.6.1169
- Author:
Christopher PIVETTI
1
;
In Chul HONG
;
Chang H YOO
;
Sun LEE
;
Kenny KIM
;
Gregory EMMANUEL
;
Jason KIM
;
Romy CHUNG
;
Slawomir NIEWIADOMSKI
;
Paul WOLF
;
R F GITTES
Author Information
1. San Diego Microsurgical Institute, USA. msurgical@yahoo.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pancreaticoduodenal transplants;
duct-ligated pancreas transplants
- MeSH:
Animals;
Graft Rejection/pathology;
Ligation/adverse effects;
Pancreas/*pathology;
Pancreas Transplantation/*adverse effects;
Pancreatic Ducts/surgery;
Postoperative Period;
Rats;
Rats, Inbred Lew;
Rats, Sprague-Dawley;
Research Support, Non-U.S. Gov't;
Transplantation, Homologous;
Transplantation, Isogeneic
- From:Yonsei Medical Journal
2004;45(6):1169-1172
- CountryRepublic of Korea
- Language:English
-
Abstract:
Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.
