Gastric Carcinoma with Lymphoid Stroma: Pathologic and immunohistochemical study of 14 cases.
- Author:
Eun Hee LEE
;
Woo Young JANG
;
Kyoung Chan CHOI
;
Young Ran SHIM
;
Joon Hyuk CHOI
;
Won Hee CHOI
- Publication Type:Original Article
- Keywords:
Gastric carcinoma;
Lymphoid stroma;
Pathology;
Prognosis
- From:Korean Journal of Pathology
1996;30(2):115-120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A total of 672 surgically resected gastric carcinomas were reviewed, and fourteen cases(2.1%) of "gastric carcinoma with lymphoid stroma" were identified. The tumor was located mostly in cardia and body portion(86%). Thirteen patients one was lost to follow up were alive without recurrence of tumor. Grossly, this carcinoma was characterized by an expanding growth pattern or a multinodular pattern. Histologically, this carcinoma showed an irregular trabecular and alveolar arrangement and densely infiltrated lymphoid cells with lymph follicles. The tumor cell nests were widely separated by non-desmoplastic lymphoid stroma. On immunohistochemical study, T cells were evenly distributed throughout the tumor lesion with intimate contact with individual carcinoma cells, but B cells were mainly present within the germinal centers of lymph follicles. Thus, the organized immune response combined with cell mediated and humoral immunities against the carcinoma cells may be a defense mechanism of the host in this type of gastric carcinoma.
