Gynecologic complication of chronic graft-versus-host disease: Vaginal obstruction.
10.5468/ogs.2013.56.4.277
- Author:
Junsik PARK
1
;
Tae Hee KIM
;
Hae Hyeog LEE
;
Soo Ho CHUNG
;
Daegeun LEE
Author Information
1. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. heeobgy@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Graft vs host disease;
Hematocolpos;
Peripheral blood stem cell transplantation;
Vagina
- MeSH:
Amenorrhea;
Consolidation Chemotherapy;
Female;
Graft vs Host Disease;
Gynecology;
Hematocolpos;
Hematologic Neoplasms;
Hormone Replacement Therapy;
Humans;
Leukemia, Myeloid, Acute;
Menstrual Cycle;
Peripheral Blood Stem Cell Transplantation;
Porphyrins;
Vagina
- From:Obstetrics & Gynecology Science
2013;56(4):277-280
- CountryRepublic of Korea
- Language:English
-
Abstract:
Allogenic peripheral blood stem cell transplantation (Allo-PBSCT) is being used to treat hematological malignancies with increasing frequency. Graft-versus-host disease (GvHD) is a complex complication of PBSCT. A 43-year-old woman came to the gynecology clinic for amenorrhea. She had been diagnosed with acute myeloid leukemia 2 years earlier and treated with induction and consolidation chemotherapy. After developing complete remission, she underwent Allo-PBSCT. When she started chemotherapy, her menstrual cycle completely disappeared. Fourteen months after menopausal hormone replacement therapy, it was discovered that her upper vaginal canal was completely obstructed. The lower vagina had an atrophic appearance. We report a rare case of partial vaginal obstruction as a complication of chronic GvHD and review the literature. We expect that this case report provides an opportunity to remind clinician of the gynecologic complications of GvHD.
