Castleman's Disease with Cutaneous Involvement Manifestating as Multiple Violaceous Plaques on Entire Body.
10.5021/ad.2011.23.S2.S169
- Author:
Hyeon Young PARK
1
;
Je Jung LEE
;
Jee Bum LEE
;
Seong Jin KIM
;
Seung Chul LEE
;
Young Ho WON
;
Sook Jung YUN
Author Information
1. Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. sjyun@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Angiofollicular lymphoid hyperplasia;
Castleman's disease;
Giant lymph node hyperplasia;
Skin
- MeSH:
Aged;
Anemia;
B-Lymphocytes;
Biopsy;
Giant Lymph Node Hyperplasia;
Humans;
Hypergammaglobulinemia;
Hyperplasia;
Hypoalbuminemia;
Leg;
Lymph Nodes;
Lymphoproliferative Disorders;
Physical Examination;
Plasma Cells;
Scalp;
Skin;
Thrombocytosis
- From:Annals of Dermatology
2011;23(Suppl 2):S169-S174
- CountryRepublic of Korea
- Language:English
-
Abstract:
Castleman's disease (CD) is an uncommon B-cell lymphoproliferative disorder characterized by lymph node hyperplasia with vascular proliferation. Cutaneous involvement in CD is rare. A 65-year-old man presented with a 7-year history of gradually developing multiple reddish to violaceous indurated plaques on the scalp, trunk, and legs. On physical examination, there were palpable enlarged cervical, axillary, and inguinal lymph nodes. Laboratory examination revealed anemia, thrombocytosis, hyperproteinemia, hypoalbuminemia, and polyclonal hypergammaglobulinemia. An inguinal lymph node biopsy and a skin biopsy were performed and the patient was diagnosed with the plasma cell type of CD. Chemotherapy was started and the lesions have responded to treatment.
