Graft-versus-host disease after kidney transplantation.
10.4174/jkss.2011.80.Suppl1.S36
- Author:
Jong Man KIM
;
Sung Joo KIM
;
Jae Won JOH
;
Choon Hyuck David KWON
;
Kee Taek JANG
;
Jungsuk AN
;
Chang Seok KI
;
Eun Suk KANG
;
Milljae SHIN
;
Bok Nyeo KIM
;
Suk Koo LEE
- Publication Type:Case Report
- Keywords:
Graft-versus-host disease;
Human leukocyte antigen;
Kidney donation;
Kidney transplantation
- MeSH:
Biopsy;
Colon;
Diarrhea;
Exanthema;
Female;
Fever;
Graft vs Host Disease;
Heart Failure;
Humans;
Hypertension;
Kidney;
Kidney Failure, Chronic;
Kidney Transplantation;
Leukocytes;
Middle Aged;
Multiple Organ Failure;
Pneumonia;
Renal Insufficiency;
Thrombocytopenia;
Tissue Donors
- From:Journal of the Korean Surgical Society
2011;80(Suppl 1):S36-S39
- CountryRepublic of Korea
- Language:English
-
Abstract:
Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients.
