Discrimination Between Childhood Subacute Necrotizing Lymphadenitis and Nonspecific Cervical Lymph Hyperplasia for Earlier Diagnosis.
10.7581/pard.2011.21.4.326
- Author:
Eun Jin CHUNG
1
;
Young Hee KWON
;
Yeo Sun JANG
;
Hey Sung BAEK
;
Ki Seok JANG
;
Chan Kum PARK
;
Jeong Seon PARK
;
Jae Won OH
;
Ha Baik LEE
Author Information
1. Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea. hablee@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Kikuchi-Fujimoto disease;
Subacute necrotizing lymphadenitis;
Reactive hyperplasia
- MeSH:
Age of Onset;
Biopsy;
Biopsy, Fine-Needle;
Child;
Discrimination (Psychology);
Female;
Fever;
Histiocytic Necrotizing Lymphadenitis;
Humans;
Hyperplasia;
Lymph Nodes;
Lymphadenitis;
Male;
Necrosis
- From:Pediatric Allergy and Respiratory Disease
2011;21(4):326-333
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We conducted this research to make an earlier diagnosis and identify better treatment for Kikuchi-Fujimoto disease (KFD) by comparing clinical findings with nonspecifically enlarged cervical lymph nodes in children. METHODS: Nineteen patients were diagnosed with KFD by tissue pathology from a fine needle aspiration biopsy and/or excisional biopsy and were compared with the clinical, radiological, and pathological findings of reactive hyperplasia. RESULTS: The average onset age of onset for patients with KFD was 11.8+/-3.61 years, and the male to female ratio was 1:1.1, whereas patients with reactive hyperplasia were 11.8+/-5.96 years, and the male to female ratio was 1.7:1. Patients with KFD suffered more from fever than patients with reactive hyperplasia (68% vs. 13%, P=0.002). Patients with KFD showed perinodal infiltration (P=0.001) and necrosis on computed tomography, whereas patients with reactive hyperplasia did not show any of these findings. Ultrasonographic findings were similar between the two study groups. In contrast, the histopathological examinations of biopsied cervical lymph nodes were enormously helpful for distinguishing the findings of KFD from those of patients with reactive hyperplasia. CONCLUSION: We recommend a histopathological examination to distinguish KFD from reactive hyperplasia in children with significantly enlarged cervical lymph nodes.
