Four Cases of Drug Allergy Caused by Non-Steroidal Anti-Inflammatory Drugs in Children.
10.7581/pard.2011.21.4.344
- Author:
Geun Mi PARK
1
;
Ju Hee SEO
;
Hyung Young KIM
;
Jinho YU
;
Soo Jong HONG
Author Information
1. Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Non-steroidal anti-inflammatory agents;
Allergy;
Drug hypersensitivity;
Oral provocation test
- MeSH:
Acetaminophen;
Anti-Inflammatory Agents, Non-Steroidal;
Child;
Diclofenac;
Drug Hypersensitivity;
Humans;
Hypersensitivity;
Ibuprofen;
Immunoglobulins;
Prostaglandin-Endoperoxide Synthases;
Pyrazoles;
Sulfonamides;
Celecoxib
- From:Pediatric Allergy and Respiratory Disease
2011;21(4):344-349
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), which reduce the production of prostaglandin by inhibiting cyclooxygenase (COX), are widely used in children as antipyretic, analgesic, or anti-inflammatory drugs. They are known to be a major cause of pediatric drug allergies, which are diagnosed by a drug provocation test. The mechanism comprises an immunoglobulin E- or T cell-mediated immune reaction or pseudoallergy caused by the inhibition of COX-1. The diagnosis of NSAIDs drug allergy requires a differential, because there is a high cross-reactivity between NSAIDs. In this study, oral provocation tests with ibuprofen, acetaminophen, diclofenac and celecoxib were carried out, and various types of NSAIDs and acetaminophen allergies were observed. Safe drugs were recommended for each patient according to the test results. We report four cases of NSAIDs and acetaminophen allergy and include the results of oral provocation tests.
