A case of rapidly progressive renal failure induced by cadmium intoxication.
- Author:
Eun Young LEE
1
;
Ho Sik SHIN
;
Yeon Soon JUNG
;
Bong Kwon CHUN
;
Hark RIM
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. kidney@hanmail.net
- Publication Type:Case Report
- Keywords:
Kidney failure;
Fanconi syndrome;
Cadmium
- MeSH:
Adult;
Asian Continental Ancestry Group;
Biopsy;
Cadmium;
Creatinine;
Fanconi Syndrome;
Female;
Humans;
Reference Values;
Renal Insufficiency;
Urinalysis
- From:Korean Journal of Medicine
2010;78(6):761-765
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cadmium (Cd)-induced renal damage primarily affects the cellular and functional integrity of the proximal tubules. Cd intoxication is a rare cause of Fanconi syndrome. We report a 31-year-old woman with Fanconi syndrome confirmed by laboratory findings and a renal biopsy that also showed an elevated urinary Cd. Seven months before admission, the patient had a normal urinalysis and renal function. Six and 3 months before admission, the patient ingested Chinese herbal mixtures. On admission, the blood Cd concentration was normal, and the urine Cd concentration was 58 microgram/g of creatinine, 29-times higher than the normal range. A renal biopsy showed degeneration of the proximal tubules with normal glomeruli. The serum creatinine had increased from 1.2 to 3.2 mg/dL over 8 months. This case of Fanconi syndrome and rapidly progressive renal damage over a short period was associated with elevated urinary Cd levels.
