Clinical Features of Drug-induced Liver Injury According to Etiology.
10.3346/jkms.2015.30.12.1815
- Author:
Byoung Moo LEE
1
;
Woong Cheul LEE
;
Jae Young JANG
;
Pyoung AHN
;
Jin Nyoung KIM
;
Soung Won JEONG
;
Eui Ju PARK
;
Sae Hwan LEE
;
Sang Gyune KIM
;
Sang Woo CHA
;
Young Seok KIM
;
Young Deok CHO
;
Hong Soo KIM
;
Boo Sung KIM
Author Information
1. Institute for Digestive Research, Digestive Disease Center, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Seoul, Korea. jyjang@schmc.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Drug-induced Liver Injury;
Hepatotoxicity;
Etiology;
Plants, Medicinal;
Traditional Therapy;
Prescribed Medicines
- MeSH:
Adult;
Alanine Transaminase/blood;
Aspartate Aminotransferases/blood;
Dietary Supplements/adverse effects;
Drug-Induced Liver Injury/enzymology/*etiology/pathology;
Female;
Humans;
Male;
Middle Aged;
Phytotherapy/adverse effects;
Plant Preparations/adverse effects;
Prescription Drugs/adverse effects;
Republic of Korea;
Retrospective Studies
- From:Journal of Korean Medical Science
2015;30(12):1815-1820
- CountryRepublic of Korea
- Language:English
-
Abstract:
Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
