The Expression of Death Domain Receptor-3, Caspase-10, Insulin-Like Growth Factor Binding Protein-3 in the Placentas of Preeclampsia.
- Author:
Won Young PAIK
1
;
Won Jun CHOI
;
Soon Ae LEE
;
Jong Hak LEE
;
Wan Sung CHOI
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University, Jinju, Korea. wypaik@gshp.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
DDR-3;
Caspase-10;
IGFBP-3;
Placental apoptosis;
Preeclampsia
- MeSH:
Apoptosis;
Caspase 10*;
Insulin-Like Growth Factor Binding Protein 3;
Placenta*;
Pre-Eclampsia*;
Pregnancy;
RNA, Messenger
- From:Korean Journal of Perinatology
2002;13(4):399-405
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine that preeclampsia is associated with differential expression of death domain receptor-3(DDR-3), caspase-10, and insulin-like growth factor binding protein-3(IGFBP-3). METHODS: Placenta were collected from 10 preeclampsias and from 15 normal pregnancies and the samples were immediately frozen and stored at -70degrees C. Total mRNA was extracted from placental tissue and then analysis of the expressions of DDR-3, caspase-10, and IGFBP-3 were performed by quantitative RT-PCR. RESULTS: Quantitative RT-PCR analysis demonstrated significantly increased DDR-3 and caspase-10 expression levels and significantly decreased IGFBP-3 expression level in the placenta of preeclampsia compared with normal pregnancy. CONCLUSION: Placental apoptosis is associated with DDR-3, caspase-10, and IGFBP-3. These results may be one of possible mechanisms in the placental apoptosis of preeclampsia.
