Altered Expression of p53, p21WAF1, p16, Rb, Smad4 and c-erbB-2 in Resected Pancreatic Ductal Adenocarcinoma.
- Author:
Yun Kyung KANG
1
;
Woo Ho KIM
Author Information
1. Department of Pathology, Inje University Seoul Paik Hospital, Seoul, Korea. jadepaka@hanmail.net
- Publication Type:Original Article
- Keywords:
Carcinoma;
Pancreatic Ductal;
Genes;
Tumor suppressor;
Receptor;
erbB-2;
Immunohistochemistry
- MeSH:
Adenocarcinoma*;
Genes, Tumor Suppressor;
Immunohistochemistry;
Pancreatic Ducts*
- From:Korean Journal of Pathology
2002;36(6):382-388
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Our aim was to undertake a comprehensive analysis of the expression of key molecular markers in a series of pancreatic ductal adenocarcinomas and to determine their association with clinicopathologic variables. METHODS: By using immunohistochemical staining, we examined the expressions of five tumor suppressor genes (p53, p21WAF1, p16, Rb, Smad4) and a growth factor receptor (c-erbB-2) in 52 surgically resected pancreatic ductal adenocarcinomas. RESULTS: Abnormal nuclear overexpression of p53 was noted in 28/52 (53.8%) cases. Total loss of p21WAF1, p16, Rb, and Smad4 was detected in 15/52 (28.8%), 33/52 (63.5%), 4/52 (7.7%), and 26/52 (50%) cases, respectively. Overexpression of c-erbB-2 was noted in 21/52 (40.4%) cases. Forty-nine (94.2%) cases revealed aberration of at least one of the markers examined. There was a positive correlation between p53 and c-erbB-2 overexpression (p<0.05). Among the examined genes, overexpression of c-erbB-2 was found to have a positive relationship with the tumor stage (p<0.05). There was also a significant correlation between the histologic grade and the number of abnormally expressed genes per tumor (p<0.05). CONCLUSION: Among the various tumor-associated proteins evaluated in this study, c-erbB-2 could have the most likely clinical implication.
