Flow cytometric analysis of DNA ploidy in primary non-small cell carcinoma of the lung in Korea.
10.3349/ymj.1993.34.4.365
- Author:
Seon Hee CHEON
1
;
Hee Young SOHN
;
Joon CHANG
;
Se Kyu KIM
;
Eun Hee KO
;
Sung Kyu KIM
;
Won Young LEE
;
Doo Yun LEE
;
Dong Hwan SHIN
;
Eun Taik JEONG
;
Hun Taeg CHUNG
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Flow cytometry;
ploidy;
non-small cell carcinoma;
lung
- MeSH:
Adult;
Aged;
Carcinoma, Non-Small-Cell Lung/*genetics;
DNA/*genetics;
Female;
*Flow Cytometry;
Human;
Korea;
Lung Neoplasms/*genetics;
Male;
Middle Age;
*Ploidies
- From:Yonsei Medical Journal
1993;34(4):365-370
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flow cytometrically determined nuclear DNA content has been measured on 74 formalin-fixed, paraffin embedded specimens of non-small cell carcinoma of the lung. Of the 60 tumors that were successfully analyzed, 32 (53%) were diploid and 28 (47%) were aneuploid. The mean DNA index of aneuploid tumor was 1.5 +/- 0.25, ranging from 1.1 to 2.0. There was no significant correlation between DNA ploidy and the patient's clinical characteristics, histology of tumor, nodal status or tumor stage. Tumor ploidy was not found as a prognostic determinant in non-small cell carcinoma of the lung in this study.
