A Case of Combining Intravenous Immunoglobulin and Leflunomide for BK Nephropathy.
- Author:
Sun Young CHO
1
;
Jeong Mo BAE
;
Woo Jin NAM
;
Jin Gun KIM
;
Su Hyun KIM
;
Dong Jin OH
;
Suk Hee YU
Author Information
1. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. sh76so@cau.ac.kr
- Publication Type:Case Report
- Keywords:
BK virus;
Immunoglobulin;
Kidney transplantation;
Leflunomide
- MeSH:
BK Virus;
Cytosine;
Humans;
Immunoglobulins;
Immunoglobulins, Intravenous;
Immunosuppression;
Immunosuppressive Agents;
Isoxazoles;
Kidney Transplantation;
Organophosphonates;
Transplantation, Homologous;
Transplants
- From:Korean Journal of Medicine
2011;81(4):512-516
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BK virus nephropathy has emerged as an important cause of renal allograft dysfunction. It affects 1-10% of renal transplant patients and results in significant graft dysfunction in more than 50% of cases. A reduction in the amount of immunosuppressants is not an appropriate treatment option for advanced stage BK nephropathy; therefore, other treatment strategies need to be considered such as cidofovir, leflunomide, and intravenous immunoglobulin (IVIG) in combination with reduced immunosuppression. The use of IVIG may be a valuable treatment option in patients with BK virus nephropathy. We report our experience with IVIG rescue therapy in a patient and the progression of BK nephropathy despite leflunomide therapy.
