Systemic Lupus Erythematosus Preceded by Distal Renal Tubular Acidosis.
- Author:
Jin Young KANG
1
;
Jong Wan KANG
;
Ji Hun KIM
;
Mi Kyung JIN
;
Churl Hyun IM
;
Eon Jeong NAM
;
Young Mo KANG
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. ymkang@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Lupus Erythematosus, Systemic;
Acidosis, Renal Tubular;
Tubulointestitial nephritis
- MeSH:
Acidosis;
Acidosis, Renal Tubular;
Adult;
Female;
Humans;
Hypokalemia;
Lupus Erythematosus, Systemic;
Nephrocalcinosis;
Sjogren's Syndrome
- From:Korean Journal of Medicine
2011;81(4):533-536
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Distal renal tubular acidosis (RTA) is characterized by a decreased net H+ secretion in the collecting tubules, which results in a failure of urine acidification and results in metabolic acidosis, hypokalemia, and nephrocalcinosis. The acquired form of distal RTA is associated with tubulointerstitial involvement of immune-mediated disorders such as Sjogren's syndrome and systemic lupus erythematosus (SLE). Only a few case reports have indicated that distal RTA precedes SLE by months to years. We present a 39-year-old woman who had manifestations of distal RTA for 21 years before the development of overt symptoms of SLE.
