Morphological Changes of Retinal Pigment Epithelium After Experimental Retinal Detachment.
- Author:
Young Bock HAN
1
Author Information
1. Department of Ophthalmology, College of Medicine, Ewha Woman's University, Korea.
- Publication Type:Original Article
- Keywords:
Retinal detachment;
RPE;
Fibrocyte-like cells;
Collagen fiber
- MeSH:
Basement Membrane;
Collagen;
Cytoplasm;
Intercellular Junctions;
Melanins;
Retinal Detachment*;
Retinal Pigment Epithelium*;
Retinaldehyde*
- From:Journal of the Korean Ophthalmological Society
1992;33(2):159-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
After the rhegmatogenous retinal detachment was induced experimentally in the rabbit eyes, ultrastructural changes in the retinal pigment epithelium (RPE) were studied with electron microscope. After 3 days of retinal detachment, apical portion of the retinal pigment epithelium was mounded and apical processes were shortened, widened and reduced in number. In other areas proliferative changes were observed in the RPE and some of the proliferated cells migrated into the vitreal space. These changes were more progressed with time. Three weeks after retinal detachment, there were areas of fibroblast-like cells proliferation with production of collagen fibers. From the evidence of cell junctions, melanin granules in the Cytoplasm and basement membrane formation, proliferated fibroblast-like cells were thought to be originated from the RPE cells.
