Clozapine-Induced Acute Hepatitis.
- Author:
Soon Joo JANG
1
;
Ho Taek YI
;
Ju Hee PAEK
;
Sang Yeon LEE
Author Information
1. Department of Neuropsychiatry, Seoul Red Cross Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Clozapine;
Liver enzyme;
Acute hepatitis
- MeSH:
Chlorpromazine;
Cholestasis;
Clozapine;
Cytochrome P-450 Enzyme System;
Drug-Induced Liver Injury;
Hepatitis*;
Humans;
Liver
- From:Journal of Korean Neuropsychiatric Association
1999;38(1):227-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors report two cases of clozapine-induced acute hepatitis. Two patients developed asymptomatic hepatitis and got better with conservative care. We decreased the dosage of clozapine and added hepatic protectors, resulting in normalized laboratory findings. The authors also reviewed side effects of clozapine in this report. We reviewed the suggested mechanism of either clozapine or chlorpromazine-induced hepatitis. Clozapine influences the liver cell via cytochrome P 450 and chlorpromazine does so via mild cholestasis. There may be a possibility that a patient who has experienced drug-induced hepatitis is vulnerable to clozapine-induced acute hepatitis. In this respect, those who have experienced drug-induced hepatitis must be observed more closely.
