Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features.
10.3345/kjp.2015.58.11.427
- Author:
Sook Hyun PARK
1
;
Gi Min LEE
;
Jung Eun MOON
;
Heng Mi KIM
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. hmkim@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Vitamin D;
25-hydroxyvitamin D;
Premature infant
- MeSH:
Alkaline Phosphatase;
Birth Weight;
Calcium;
Diabetes, Gestational;
Female;
Gestational Age;
Gyeongsangbuk-do;
Humans;
Incidence;
Infant, Newborn;
Infant, Premature*;
Membranes;
Parturition;
Pre-Eclampsia;
Pregnancy;
Rupture;
Twins;
Vitamin D Deficiency*;
Vitamin D*;
Vitamins*
- From:Korean Journal of Pediatrics
2015;58(11):427-433
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency. METHODS: A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as maternal gestational diabetes, premature rupture of membranes, maternal preeclampsia, birth date, gestational age, and birth weight. RESULTS: Mean gestational age was 33(+5)+/-2(+2) weeks of gestation and mean 25-OHD concentrations were 10.7+/-6.4 ng/mL. The incidence of vitamin D deficiency was 91.7%, and 51.1% of preterm infants were classified as having severe vitamin D deficiency (25-OHD<10 ng/mL). The serum 25-OHD concentrations did not correlate with gestational age. There were no significant differences in serum 25-OHD concentrations or incidence of severe vitamin D deficiency among early, moderate, and late preterm infants. The risk of severe vitamin D deficiency in twin preterm infants was significantly higher than that in singletons (odds ratio, 1.993; 95% confidence interval [CI], 1.137-3.494, P=0.016). In the fall, the incidence of severe vitamin D deficiency decreased 0.46 times compared to that in winter (95% CI, 0.227-0.901; P=0.024). CONCLUSION: Most of preterm infants (98.9%) had vitamin D insufficiency and half of them were severely vitamin D deficient. Younger gestational age did not increase the risk of vitamin D deficiency, but gestational number was associated with severe vitamin D deficiency.
