Prognostic Significance of DNA Content and S-Phase Fraction in Gastric Carcinomas.
- Author:
Sukyung HWANG
1
;
Junho LEE
;
Sunghoon NOH
;
Kangyoung LEE
;
Seungho CHOI
;
Jinsik MIN
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Gastric carcinoma;
Prognosis;
DNA flow cytometry
- MeSH:
Aneuploidy;
Diploidy;
DNA*;
Flow Cytometry;
Humans;
Ploidies;
Prognosis;
Recurrence
- From:Journal of the Korean Surgical Society
2000;59(5):602-608
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: DNA flow cytometry is a simple and easy method to assess the DNA content and the cell-cycle distribution of a tumor cell. The prognostic significance of the DNA content and the S-phase fraction in a gastric carcinoma has been controversial. The purpose of this study was to evaluate the prognostic significance of the nuclear DNA content and the S-phase fraction in patients with a gastric carcinoma. METHODS: Between May 1995 and March 1996, 94 patients who were underwent a gastric resection for a gastric carcinoma were evaluated with DNA flow cytometry. Of them, 88 patients underwent a gastric resection with curative intent. The relationship of variable clinicopathological factors and of recurrence pattern to survival and nuclear DNA content were assessed. RESULTS: The mean age was 55 years. 55 patients (58.5%) exbitied diploidy and 39 patients (41.5%) aneuploidy. There was no relationship between the clinicopathological factors and either the ploidy pattern or the S-phase fraction. Though the recurrence and its pattern were not different between the two ploidy group (p=0.860, 0.137), diploidy tended to recur locoregionally and aneuploidy hematogenously. CONCLUSION: The ploidy pattern was a significant prognostic factor in gastric carcinomas, but should be interpreted carefully.
