Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats.
10.3346/jkms.2005.20.1.132
- Author:
Bae Hwan LEE
1
;
Kyung Hee LEE
;
Do Heum YOON
;
Un Jeng KIM
;
Yong Soon HWANG
;
Sang Keun PARK
;
Joong Uhn CHOI
;
Yong Gou PARK
Author Information
1. Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. electro@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Spinal Cord Injuries;
Methylprednisolone;
Behavior;
Evoked Potentials;
Recovery of Function
- MeSH:
Animals;
Disease Models, Animal;
Electrophysiology;
Evoked Potentials, Motor/*drug effects;
Free Radicals;
Glucocorticoids/metabolism;
Male;
Methylprednisolone/*pharmacology;
Neurons/*drug effects;
Oxygen/metabolism;
Rats;
Rats, Sprague-Dawley;
Receptors, Glucocorticoid/metabolism;
Research Support, Non-U.S. Gov't;
Sodium Chloride/pharmacology;
Spinal Cord/pathology;
Spinal Cord Injuries/*drug therapy;
Time Factors
- From:Journal of Korean Medical Science
2005;20(1):132-138
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to salinetreated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.
