Elevated plasma fibrinogen levels and prognosis of epithelial ovarian cancer: a cohort study and meta-analysis.
- Author:
Yanlin LUO
1
;
Hee Seung KIM
;
Miseon KIM
;
Maria LEE
;
Yong Sang SONG
Author Information
- Publication Type:Meta-Analysis ; Original Article
- Keywords: Fibrinogen; Survival; Ovarian Neoplasms, Meta-Analysis
- MeSH: Biomarkers; Blood Platelets; Cohort Studies*; Disease-Free Survival; Fibrinogen*; Humans; Lymphocytes; Neutrophils; Ovarian Neoplasms*; Plasma*; Prognosis*
- From:Journal of Gynecologic Oncology 2017;28(3):e36-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate the effect of elevated plasma fibrinogen levels on the prognosis of epithelial ovarian cancer (EOC). METHODS: We reviewed the data of 217 patients with advanced-stage EOC between 2000 and 2012, and investigated the prognostic role of elevated plasma fibrinogen levels compared with serum CA-125 levels, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). For further evaluation, we performed a meta-analysis using 5 cohort studies published to July 2015, including our cohort study after a literature review. RESULTS: Among the four biomarkers, only plasma fibrinogen levels >485.2 mg/dL were correlated with impaired progression-free survival (PFS) and overall survival (OS) (median, 13.9 vs. 20.3 months and 42.2 vs. 55.4 months; p<0.010). Elevated plasma fibrinogen levels were an independent factor for poor PFS with marginal significance and OS (adjusted hazard ratios [HRs]=1.389 and 1.581; 95% confidence intervals [CIs]=0.979–1.972 and 1.032–2.423, respectively). Furthermore, crude and subgroup meta-analyses demonstrated that elevated plasma fibrinogen levels were associated with impaired PFS and OS in patients with all stage EOC. CONCLUSION: Elevated plasma fibrinogen levels be more important for predicting survival than serum CA-125 levels, NLR and PLR in patients with EOC, in particular, advanced-stage disease. Moreover, it may be related to poor prognosis of EOC.
