Multicenter clinical study on birth weight and associated anomalies of single umbilical artery.
10.3345/kjp.2009.52.6.655
- Author:
Su Nam BAE
1
;
Jae Woo LIM
;
Kyong Og KO
;
Hyun Seung JIN
;
Min Hee KIM
;
Bo Young LEE
;
Chun Soo KIM
;
Eun Ryoung KIM
;
Sang Kee PARK
;
Jung Joo LEE
Author Information
1. Department of Pediatrics, College of Medicine, Konyang University, Korea. limsoa@hanmail.net
- Publication Type:Multicenter Study ; Original Article ; In Vitro
- Keywords:
Umbilical artery;
Congenital malformation
- MeSH:
Birth Weight;
Central Nervous System;
Fertilization in Vitro;
Heart Diseases;
Hospitals, University;
Humans;
Hydronephrosis;
Incidence;
Infant;
Korea;
Live Birth;
Parturition;
Physical Examination;
Prognosis;
Retrospective Studies;
Single Umbilical Artery;
Umbilical Arteries;
Urogenital Abnormalities;
Urogenital System
- From:Korean Journal of Pediatrics
2009;52(6):655-660
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare birth weight between infants with a single umbilical artery (SUA) and normal infants, investigate the associated anomalies of infants with SUA and isolated SUA (no abnormality of external appearance on birth, except SUA), and determine the prognosis of infants with isolated SUA. METHODS: Live-born infants with SUA (n=59) detected by physical examination from among 15,193 live births in seven university hospitals in Korea between January 1, 2004, to August 1, 2007, were reviewed retrospectively, with 236 normal infants serving as the control group. RESULTS: A statistical difference was observed between the groups in birth weight and in vitro fertilization. The incidence of infants with SUA was 0.37%. Congenital malformations were observed in 21 infants with cardiovascular (n=15, 25.4%), gastrointestinal (n=2, 3.4%), genitourinary (n=9, 15.3%), neuromusculoskeletal (n=6, 10.2%), central nervous system (n=1, 1.7%), chromosomal (n=1, 1.7%), and other (n=3, 5.1%) abnormalities. There were 49 (83.1%) infants with isolated SUA in this study population; among them, the associated congenital malformations were cardiovascular (n=6, 12.2%) and genitourinary (n=6, 12.2%) abnormalities. Two infants with cyanotic heart disease were operated and four infants with acyanotic heart disease showed improvements without any treatment. Six infants with genitourinary abnormalities on renal ultrasound had mild hydronephrosis without further consequences. CONCLUSION: The incidence of structural abnormalities in the cardiovascular and genitourinary systems is high and the genitourinary anomalies associated with isolated SUA have relatively good prognosis.
